Dermaroller 10. DHT Blockers for Hair Loss: An In-Depth Overview, 5 Best LLLT Devices: Laser Treatment for Hair Loss, https://doi.org/10.1016/0960-0760(94)90250-X, https://doi.org/10.1046/j.1365-2133.1997.19382053.x, https://international.kyowa-kirin.com/share/pdf/press-release-prostrakan-rebrands-as-kyowa-kirin-18-04-16.pdf, https://www.infona.pl/resource/bwmeta1.element.elsevier-391c502a-853e-3678-ad3c-1984832583e4/tab/summary, https://www.infona.pl/resource/bwmeta1.element.elsevier-5d8b8e9a-87d8-3665-a251-1f766eb8cef1. Many claimed that this "magic pill" has helped grow back stubborn hairs in areas considered irreversibly damaged. 4. Place your beaker/cup bottle on top of the scale, measure out your 3 grams of RU58841 and place it inside. Ive only been using for 2 weeks so cant provide a 5 star rating, yet. As opposed to pre-mixed RU58841 solutions, all RU58841 raw powder (unmixed) should always be kept in the freezer. The main aim of these scientists was to develop a potent medication that would effectively manage acne and androgenic alopecia when applied topically while avoiding/limiting systemic side effects that are commonly observed with other anti-androgens. RU58841 can be either bought in a pre-made solution or as the raw powder form. Necessary cookies are absolutely essential for the website to function properly. Once you press this, it will reset the scale to 0 even with the beaker on it. Subscribe and get my 20 Underground Bodybuilding Secrets You Wont Find On Google E-Book 100% FREE, There are advantages and disadvantages to mixing your RU58841 with Minoxidil liquid, What You Will Need To Mix Your Own RU58841 And Minoxidil Combination Solutions, Adding The RU58841 Powder To The Minoxidil Liquid Solution, Cheaper if you already use Minoxidil liquid every day, Efficient as Minoxidil already comes in separate 60 ml bottles (very close to the standard 50ml PG + Ethanol solutions we use to measure and mix our RU58841, Requires that you use Minoxidil every single time you apply RU58841 because they are mixed. I got my package within 3 days. Been using it for 9 months. The best way to reach us is by using our contact form. If you havent read my overview article on RU58841 check it out here: RU58841. It is also known as PSK3841 or HMR3841. This category only includes cookies that ensures basic functionalities and security features of the website. During the trial phase of the mediation, the RU58841 results were very promising. Have recommended your Company to 3 friends and ALL are very happy with outcome. The next procedure depends on whether you are using other hair treatments as well. Allow me to explain this, as I used to recommend storing all RU58841 (mixed and unmixed) in the freezer. These are the only companies I currently use for my own personal research: Anageninc, Chemyo. Well done guide my man, but do you have any before/after pictures? RU-58841, also known as PSK-3841 or HMR-3841, is a nonsteroidal antiandrogen (NSAA). Although the results were apparently good and well tolerated, none of these were ever published. Before starting treatment, I thought shedding was androgen induced. The results are very encouraging which shows that the current anageninc route of synthesis is stable for at least 24 months at room temperature. Get New Research, Treatments, and Discoveries Delivered to your Inbox. and their delivery got even better. Oral Minoxidil for Hair Loss: Better than Topical? If you choose instead to add the RU direct into the Minoxidil, do it slowly and carefully (no shit). Reddit and its partners use cookies and similar technologies to provide you with a better experience. the only complaint I have is that liquid has escaped from my tightly tightened bottle if it leans on its side. This article is intended for educational / informational purposes only. RU58841 is a specific androgen receptor antagonist or a so called anti-androgen. They fixed right away without any question. This product is already mixed and ready to for use. Only issue I see is lack of safety studies, specially long term. I typically mix the RU and everclear a little more by squeezing in and squeezing out the mixed solution with the dropper. 1 Diffuse thinner here with pretty long hair. Shake and swirl the solution lightly until the RU58841 powder has completely dissolved inside the bottle, and the solution is completely clear. Essentially, to prevent degradation of the compound, you simply must make sure it's stored out of any direct light and it's in a cold enough temperature. It blocks androgens from binding, such as DHT. But opting out of some of these cookies may have an effect on your browsing experience. 2020 Copyright Online Health Networks, Inc. All Rights reserved. Great service, shipped immediately. The overall effect is really noticeable as can be seen in this RU58841 before and after comparison below. It's not bad, minoxidil has all the solvents needed to dilute the RU powder and has shown no interaction with RU so far. RU58841 Raw Powder Ethanol (Many People use Everclear (190 proof = 95%) Ethanol) Propylene Glycol A Very Accurate Digital Scale Glass Stirring Rod 2x 50ml Measuring Beakers 50ml+ Bottle To Hold Your RU58841 Solution A Funnel The Instructions First thing you want to do is grab a 50ml measuring beaker and fill it up with 35ml of Ethanol. A lot has transpired since the inception of the idea. After you have applied it, let it dry for about a minute. The mechanism of RU58841 is entirely different from other anti-androgenic medications. I don't like the fact that it has to be used or frozen so if someone has a better recipe please share or link RU58841 Recommendations Or Dosing Guidelines The things you'll need: At the same time order off of eBay or Amazon a 0.001 gram digital scale. Read More Creatine Causes Hair Loss. You must log in or register to reply here. For instance, several companies had acquired and dropped their right to this product. For now, information about its side effects can only be derived online from the reviews of customers who have actually used the product. In studies and clinical trials RU58841 has shown to; Strongly compete against DHT Increase cellular replication rate in the matrix cells It has been demonstrated to interrupt this hair loss message locally so that normal hair growth could continue. The raw powder should be stored within air-tight bags in a freezer. No crystallization occurs in the fridge though. Although RU58841 can remain potent in room temperature for a while, I put my mixed solutions into sealable 50ml bottles, and then put the bottles into a container, shut the container so no light can get in, and then put that in the fridge. It is important to store RU58841 in a dry, dark, and cool place as it degrades in heat and sunlight. US orders above $100 and International orders above $250 Qualify for free discreet shipping. A multi-centre, double-blind, randomised, vehicle-controlled study for a quantitative estimation of hair re-growth in male subjects with androgenetic alopecia treated over 6 month with two ethanolic PSK 3841 solutions (2.5% and 5%). Been wondering if there's some composition or form of RU or something to mix it with to make your scalp respond or something. We also use third-party cookies that help us analyze and understand how you use this website. Ultimately it will be up to you what you find optimal for which type of Minoxidil you use, and what fits into your hair loss prevention protocol and what doesn't. Upload your video Step 1: Get 99%+ plus RU58841 ( Current batch is from https://www.chemyo.com/ru58841.html but other sources are fine too ) Step 2: Measure 3 Grams RU58841 Step 3: Shake 1-5 minutes until the. If you follow the storage recommendation outlined above in your . Makes small dosing changes near impossible because if you want to alter your RU58841 dosage, then you will also be forced to alter your Minoxidil dosage, which could lead to unwanted side effects. It has been found to be well tolerated by the people using it, and not many side effects have been reported. The link is on the bottom right of every page. It was renamed after newer companies bought the rights to the original product, RU58841. No portion of this page may be duplicated without consent. All you need to do now is get your glass stirring rod, and stir the solution until it is crystal clear and you cant see any fragments of unmixed RU58841 powder in it. A daily dose of 50 mg applied in areas that are affected by alopecia will usually suffice. If you want to mix the standard concentration, use 2.5 grams of raw RU58841 powder in a 50ml K&B solution to achieve a 5% RU58841 solution of 50mg/ml. 154992-24-2 Purity & Quality Control Other Androgen Receptor Products Darolutamide (ODM-201) New Darolutamide (ODM-201, BAY-1841788) is a novel androgen receptor (AR) antagonist that blocks AR nuclear translocation with Ki of 11 nM. We provide full transparency on testing and all products are batch coded so that you can look up the test reports belonging to your batch. Sealed to prevent tampering during transit, https://www.propublica.org/article/the-myth-of-drug-expiration-dates, Increase cellular replication rate in the matrix cells, Increase cellular proliferation of outer root sheeth cells, Increase the percentage of hair in the anagen phase, Exert no negative effect on body hormone levels, Provide equivalent or better net growth than Finasteride. Other anti-androgenic drugs act by either reducing or blocking the synthesis of dihydrotestosterone (DHT). Great customer service! If you need to make 8% RU, you need to add 4.8 grams of RU. Been using RU from Anagen for over a year now for personal research. Copyright 2022 More Plates More Dates All Rights Reserved. Everclear Alcohol (95% / 190 Proof) 3. Written by Kartik Kumar Rathi Updated On February 1, 2023 Compound Summary Class of Compound Peptide (NSAA)/SARMs Mechanism of Action They both work fine; some people just seem to have skin irritation to particular carriers as opposed to others. Tracks are blended using various processes such as EQ, Compression and Reverb. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. For the carrier (what the RU58841 raw powder is mixed in), I prefer PG (propylene glycol) + Ethanol. Now you have a bottle of Minoxidil with 50mg of RU58841 in each ml of solution. How to apply RU58841 on whole scalp without mega dosing? It prevents miniaturization by blocking DHT, Testosterone, and other androgens from attaching to the hair follicle. The phase 1 trial involved the application of 5% solution twice daily for 4 weeks, and the phase 2 trial compared the placebo to 2.5% and 5% solutions of RU58841 for 6 months. An example is enzulutamide which is structurally similar to RU58841 and is stable for a minimum of 2 years. Getting everything in bulk would reduce the cost.. What is the reason(s) you don't just dump it in minoxidil? Videos Help others learn more about this product by uploading a video! Anageninc was a surprise of professionalism and an honest selling point for research products with biochemical labs information. RU58841 goes by several names. What also would be useful would be a list of side effects reported by long term users. I also assume you're rolling with the most popular dose of 5% strength 50mg/ml. The raw powder form is a little cheaper and gives a bit more of flexibility. Been wondering if there's some composition or form of RU or something to mix it with to make your scalp respond or something. If I see any new hairs I will increase my rating. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. If possible, consult your doctor or healthcare provider before you use this product, or when you notice symptoms after using it. 2% Formulation. Therefore androgens dont have the chance to bind and start the chain reaction of androgenetic alopecia and begin the so called miniaturization process. The monkeys experienced an increase in hair growth of 103%, compared to just 88% for those given finasteride. Though like any other RU58841 product, it is not FDA regulated. The finasteride group had serum DHT levels lowered by 70%, while the RU58841 group had no change in levels. If for any reason your package doesn't arrive, well ship out a replacement free of charge or offer you a full refund. Unfortunately, I doubt we will ever know it, Blocking 5a-reductase to tackle hair loss is like killing a fly with a bazooka. It is hoped that future studies will document the side effects of using RU58841. Just like finasteride (but minus the side effects), the effects of RU58841 are as follows: The safety and effectiveness of RU58841 are quite impressive. See this article for more information: https://www.propublica.org/article/the-myth-of-drug-expiration-dates. Phase 3. ), from Maseno University. Impressed! You should now have a cloudy solution of RU58841. It is an effort to improve information available to the users of /r/PEDs and will function as a type of skunkworks as we work on content and collaborate on research. Part the hair into one or more rows to expose the hair thinning area on the scalp. It can easily be bought on Amazon, drug store/chemist and even some grocery stores. Then you can correctly measure 30-100mg of RU for each application. 3. Once you've done that, you can turn off the scale and put it away. Suggestions? However, there is a lot of misinformation floating around on the internet about the use and side effects of DHT blockers and many unsubstantiated claims about its alternatives. Im excited to see what happens by the end of this bottle! You now have a bottle of Minoxidil with 50mg of RU58841 per ml of solution. Great product, it actually works. RU58841 | Buy RU-58841 Solution 30ML (99%+ purity), High-quality, Third-party tested. My only complaint and reason for 4 stars, is that the batch date is sometimes well past 6+ Months, sometimes ranging to a Year. You should realize that RU58841 is not an FDA-approved medication thus you must stay cautious about the usage of this product. Too soon to tell really, but Im optimistic. and our Once you see that its turned on and at 0 grams, put an empty beaker on the scale. Hypothetically, lets say you want to make a 5% strength 50mg/ml RU58841 solution (the most popular dosage/strength). Topical Finasteride for Hair Loss: Better than Oral? Product shipped fast, has the right smell, and support is great. Add to Favorites . This non steroidal topical androgen antagonist was investigated for therapeutic value in androgenetic alopecia and acne. Shipping is always incredibly fast, solid product! New Release (2016). Place your beaker/cup bottle on top of the scale, measure out your 3 grams of RU58841 and place it inside. Then simply apply the solution to the scalp and that's pretty much it. Right now, you are probably aware that hair loss occurs due to the action of DHT on the hair follicles. Follicular regrowth with 5 -reductase inhibitor (finasteride) or androgen receptor blocker (RU58841) in the bald scalp of the stumptailed macaque. Several medications are available for treating hair loss. After the measurement has stabilized, turn the scale back to 0 with the beaker still on it by pressing the Tare button. You may not even get a genuine product to begin with. First is cheaper, second is more straightforward. 2) At the same time order off of eBay or Amazon a 0.001 gram digital scale. Dries out faster in my opinion, so you might wanna check that out also. ANAGENINC WILL IMMEDIATELY DENY ANY ORDER THAT WE FEEL WILL BE USED OUTSIDE OF THE SCOPE OF ITS INTENDED PURPOSE. I keep those sealed in several ziplock bags, in another closed container to ensure no water somehow seeps in and hits the powder. RU58841 is stable for at least 2 years at room temperature. RU58841 is a nonsteroidal anti-androgen for hair loss (androgenic alopecia). How To Store RU58841 Raw Powder. The products we offer are intended for . My raw RU powder is always sealed in zip-locks though in the freezer. It's also still cold enough to offset degradation to a large degree, but not cold enough to cause crystallization of the powder in the solution basically. Another study evaluated the effectiveness of RU58841 on human hair transplanted onto the skin of nude mice. This is out of an abundance of caution, mostly. You NEED this to correctly measure 30-100mg of RU for each application. If you dont already know what RU58841 is, it is a non-steroidal experimental anti-androgen, which is intended for use as a topical treatment for acne and androgenic alopecia (male pattern baldness). These are more forgiving on sensitive scalps. Too extensive, but fast delivery and good quality. To briefly describe how it works, it is basically a turn-key all in one hair loss compound that blocks all DHT on the scalp, and can significantly improve the life of anybody experiencing hair loss, and Im shocked it isnt more heavily researched. After the measurement has stabilized, turn the scale back to 0 with the beaker still on it by pressing the Tare button. Read More DHT Blockers for Hair Loss: An In-Depth OverviewContinue. Many of the stories published online are claims from individuals who may either have a conflict of interest or are already on other hair-loss medications such as minoxidil and finasteride. However, as there have been no direct human studies for more than a decade, the FDA has not approved it for the management of any condition. Exfoliating Cream What is a 'Vehicle' They act by directly blocking the effects of androgens like testosterone and dihydrotestosterone (DHT). In general, most apply RU58841 as a topical agent (directly to the scalp) or digest it orally through a powder substance. Unfortunately, none of them are completely effective to restore your full head of hair. It does if you use enough solution for the amount of RU powder you're reconstituting, as well as shake/stir it good enough. No issues. These typically cost between $20-30 US, heres the one I use: http://i50.tinypic.com/23j28wn.jpg Pull off the cap. RU58841 Recommendations Or Dosing Guidelines The things you'll need: RU sample At the same time order off of eBay or Amazon a 0.001 gram digital scale. It is actually quite simple how to mix the two, and it simply involves some basic math. RU58841 is a non-steroidal anti-androgenic medication that was initially developed in the 1980s as a topical treatment remedy for acne and male pattern baldness - androgenetic alopecia. RU58841 (also known as PSK-3841 or HMR-3841) is a non-steroidal anti-androgen with potency (IC50 = 100 nM, Ka = 1.1 nM) which was previously investigated for use as a topical treatment for acne, androgenetic alopecia, and hirsutism. Ordered RU from this site 2 times already and I highly recommend this product. I'm talking the hard bristles. The mere fact that the effect of RU58841 does not interfere with the synthesis of DHT and testosterone, makes it a very promising drug. Thus consult your doctor and consider other tried and tested options for hair loss, like minoxidil, oral or topical finasteride (the more widely used RU58841 alternative), or laser light devices, before considering this one. You will need the following at a minimum: Step 1: Measure out 3000mg (3 grams) of RU58841 raw powder per bottle of Minoxidil by weighing it out. Dose-dependent and long term effects of RU58841 (androgen receptor blocker) on hair growth in the bald stumptailed Macaque. all in my family,Dad n Mum ,all Males are bald! This seems pretty irrelevant if you don't. Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. RU58841 (roughly $100 per 10g) 2. After dedicating over 8 years to extreme self-improvement, I have created "More Plates More Dates" as a one stop shop for helping you to get yourself on the right path to the "best you" possible too. Very fast and accommodating. Privacy Policy. We strive to achieve absolute first class customer service as well as extremely high quality products! I use a boar brush to exfoliate. You'll need to scoop up the RU powder somehow. RU58841 is a specific androgen receptor antagonist or a so called anti-androgen. Make sure to use the TARE function when you've got your small plate on the scale, obviously, this cannot be weighed as part of the RU powder so you'll need to be at 0.000 weight before beginning. Cookie Notice There are a lot of myths surrounding the proper storage of this research chemical, and Im going to quickly clarify every thing for you in this quick article. PEDsR stands for Performance Enhancing Drugs Research. K&B solution is 60% Ethanol, 35% Deionized Water, and 5% K&B Emulsifiers. My package was lost by the local postal service, contacted anagen and they sent me a free replacement the next day! The material published on hairverse.com is not intended as medical advice, diagnosis, or recommended treatment. It does not reduce the production of DHT. (like when it's shipped or caught in customs) Also, 1% RU from MPB treatments isn't enough RU, file poly kalo apotelesma , prepei na eisai paenytyxhs, sygxarhthria. Uno, H., Obana, N., Cappas, A., Rhodes, L., & Bonfils, A. Subscribe and get my 20 Underground Bodybuilding Secrets You Wont Find On Google E-Book 100% FREE. The idea to develop it was first put forth by a French pharmaceutical company called Roussel Uclaf, way back in the 1970s. Please if you do will you post them to let us see if this stuff works. Dosing at 2ml (100mg), I get a pretty high heart rate for about an hour. The problem is that any treatment which reduces DHT, usually by inhibiting 5-alpha-reductase (drugs like Finasteride), can cause side effects around the body. By clicking Accept, you consent to the use of ALL the cookies. Would a reliable member not be interested in packaging this up into monthly bundles with a small mark up and shipping to who ever signs up? We make sure quality is a top priority, and every single order we ship is checked and ensured to meet our highest in the industry standards. More like this: 5 months of hairloss treatment 37 /r/femalehairloss, 2023-04-14, 00:37:58 Has anyone seen better . Like finasteride, the stuff works by interfering with the body's production and uptake of DHT, but with a significantly shorter half life. Minoxidil. Step 1: Measure out 3000mg (3 grams) of RU58841 raw powder per bottle of Minoxidil by weighing it out. Been researching for over 3 months. We won't share your information with anyone. Otherwise, the hairs in that region will also grow thicker over a period of time. /r/tressless , 2023-03-16, 12:16:40 PLEASE FAMILIARIZE YOURSELF WITH OUR TERMS & CONDITIONS PRIOR TO ORDERING.
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