She never did that before! I gave this for the first time to my hound and about 3 hours later, she was very unsteady on her feet, eyes half shut and then had 4 episodes of breathing rapidly that each lasted 30 seconds or so and all happened within a 30 minute period. I even told them about the Simparica which they dont respond to. Our dog has not been given another dose. This Tuesday the 17th I had given my dog simparica trio for 27lbs dose. A dog fence is an important detail to consider when adopting a pet for the first time or moving your dog to a new home. We took him to a emergency Vet Hospital that pin pointed Simparica Trio as the main facture that triggered his controlled seizure episodes in having constant all day tremors & seizures hurting him to the point of making the decision to put him down or have him continue with the pain until it killed him. This content shouldnt take the place of advice by your vet. They gave him a strong shot of prednisone that was good for 2 days . The vet and company are in consultation. Called his vet and they gave no information. Getting him to go out was nearly impossible. However, these adverse effects are rarely observed in pets and overall the product is proven to be suitable for all dogs without occurrence of any side effects. Last month she had diarrhea and it lasted 7 days. She is more worried about excessive thirst, lip smacking and her kidneys. The more we complain the more chance we have of saving other dogs. Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. Our 3 mo.old Boston Terrier, 10 lbs, had her first dose of Simparaco yesterday. May not be from this med but too strange to at least not think about it. Hope your pup is doing better!! Duke is 7 month boxer And we have the simpatica on Monday and cant believe this stools Hopefully it doesnt last long. Idk what to do. Hope all is well. Bentlee trusts me an I let him down on this one. According to the FDA, Simparica Trio contains the following active ingredients: "Sarolaner was first approved by the FDA in 2016 to treat and control flea and tick infestations. There is a petition in Australia to have this drug banned through change.org, which I've signed. Simparica Trio covers the most common dog parasites and typically costs less than buying separate products. He has never done this, and when I heard it and woke up he couldn't stop. My 10 year old Standard Poodle had one dose of Simparica and had seizures two weeks later, which was yesterday. How long do the side effects of Simparica last? She text me asking if she ever had seizures before. My other two dogs had a little loose stool but nothing else. How can you give a dog a pesticide to ingest. Just our own personal experience but I won't get burned again! She seems to have aged five years since T-Day. 2-6 days in vomiting here and there. Any believers out there please say a prayer for our pup as I will for the people on this thread. Simparica Trio is not effective against adult heartworms. I gave this to my 8 yr old chihuahua and a couple days later he started having seizures. Was hospitalized for 2 1/2 days. It could be a coincidence but seems too coincidental. Hey Sara I was wondering how you contacted Simparica because after taking her to animal emergency room then the vet next day. It has been five days and the diarrhea started on day 2. It is really eye-opening to see everyone's experiences. My personal dog has had no issues at all, and she's been on it for nearly two years. Sound familiar? Her blood work came back fine. She started it on 7/22. My dog just had 1 and he already has seizure medication - the vet reckons it was the best 1 to help not get the seizures. How is ur puppy? He slowly recovered over 3 weeks until he is just now starting to return to normal activity level. Serious side effects are rare, but you should still monitor your dog after administering Trifexis and report any . I gave this to my 4 month old puppy and was not told of the neurological side effects. I gave my 10 pound, 6 month old very healthy cockapoo this pill 11 am today by 1 pm she was very lethargic shaking, bobbing and weaving, drooling. Compared to other products, the efficiency of this . Advised her to put a big note on our account that she is never to have this again. Her last dose of Simparica Trio was given to her on October 1, 2021. I just gave Bentlee my Akita Simparica Trio on the 9th. We reported it with the company and they are reimbursing for vet bills, maybe you can report as well. I gave our boy, Yogi his first dose of Simparica TRIO on 11/17/2020. As of today, Sadie's ability to eventually meet the strict certification requirements in that pursuit, remains guarded, although her progress prior to this event had been stellar. This is happening now and she is still nowhere near 100% but I am hopeful that she will eventually fully recover. Fortunately for conscientious dog moms and dads, Simparica offers a once-a-month chewable treatment that is FDA-approved and safe for Fido, taking the guesswork out of fighting fleas and ticks. Now we are out thousands of dollars when every event has been triggered by Simparica Trio. He doesn't seem to be throwing up as much anymore, he did several times throughout the night though. My 2 1/2 mini goldendoodle has been on Simparica 10 days now. Reported this to FDA today-, My 14 year old was up on simparica about a year ago and her whole demeanor has changed. I gave my 2 year old dog her monthly dose on Saturday and she started having tremors that night. The FDA has issued a warning about the potential for neurological side effects associated with isoxazoline class drugs, including Simparica Trio. We just gave the first does to our 11 week old Sheepadoodle puppy yesterday. 24 hours after, we noticed diarrhea. I'm so scared. Thank you all so much!!!! I feel like it was a massive overdose. Simparica Trio can be administered to your dog at any age, but it's best to start treating your dog . She's not drinking water or eating all she wants to do is sleep. I've read that simparica takes 35 days to get out of their system. I am continuing to recover at home and have to use an oxygen tank. Simparica 48. Twice I have seen his eyes roll into the back of his head (petti-mal seizure?) Simparica has been approved by the FDA to treat and prevent flea and tick infestations. It seems to coincide with the monthly dosage. At the vet today, I bought a single dose of Simparica Trio to try instead of Trifexis and Combogaurd, because they seem less tolerated by her now that she is older. It is recommended to wash your hands after administering this medication. (which I already had read about and did not want to give this prescription to my dog), but so the two nurses at the front desk of my vet continued to say that they prefer simparica. However, these adverse effects are rarely observed in pets and overall the product is proven to be suitable for all dogs without the occurrence of any side effects. I dont know whether its a coincidence or not, but 4 days after second dose of Simparica Trio, my dog ended up at an urgent care with blood in his urine. I would say these changes may have happened more suddenly than just normal aging so I'm not going to give him this medication anymore. He looked like he was having a seizure. Moxidectin was first approved by the FDA in 1997 for the prevention of heartworm disease in dogs. He was vomiting, had diarrhea, urinating constantly and the very scary part were the uncontrollable tremors. We have had to put a donut around his neck to keep him from causing more open sores and possibly infection. I will never give him this drug again. Vet gave her a shot which stopped it. Any response from the company? This morning was the first morning he left water in his bowl. I dont like that my dog looks at me like he doesnt know who I am. Never happened before. Simparico Trio, will not be given to my dog ever again. A week and a half from taking the drug, he is still on 3 meds, taking fluids and starting to gain strength and eat food and drink water in very small amounts. I took him in today and they think it might be meningitis. If you miss a dose of Simparica Trio, give it immediately and resume monthly dosing. Our golden retriever had his first seizure after taking Simparica Trio last October. Overly anxious. Im switching back to the old stuff. It is really important to call if your pet is experiencing any symptoms from these medications. Hoping that these side effects dont get worse and subside soon . What should I do? We got to the Animal Hospital . This medicine is making her shaky/tremor, anxious, and she is panting a ton. That was when I lived in Fort Lauderdale. For the vast majority of . His neck felt swollen and he was panting heavily gasping for air. I don't want another animal harmed by this stuff, one animal is one to many. I called my vet but because of Covid they are so behind in appts and would not see him until a month from then. The vet doesn't seem to really want to blame it on Simperica Trio and wants to treat these symptoms which he says are life threatening. After reading all your entries, i'm thrilled i chose to take her off of it. Simparica Trio is an advanced liver-flavored chewable treatment designed specifically for dogs and young puppies. Hi there, So sorry to hear about your dog. Thank you for this information. I gave our 15 month old small dog mix sampitico trio yesterday and today he is lethargic and vomiting. The most common adverse reactions in clinical trials were vomiting and diarrhea. The vets and neurologists say it's not simparica trio - but she was perfectly healthy until that dose was given. It has been 20 days since I gave her the prescribed dose of Simparica. Any advice on the diarrhea? so what about her puppies I am so worried. This drug needs to be pulled off the market! Could this be caused by the med? after a few months of this i decided to go back to Sentinel and Bravecto. This happened the same to my dog.. how si going now with your pet? Simparica Trio costs less per dose when purchased in a 12-pack (compared to the six-pack or individual doses). In a third field safety and effectiveness study, Simparica TRIO was administered to 120 dogs with roundworms. After reading all of supporting reviews, I will never give him this again. I took her home. When fleas or ticks bite, they are exposed to its FDA-approved ingredient sarolaner, the insecticide, and acaricide that kills parasites fast. my dog became extremely itchy all over her body. He had full wellness exam three ago and was in perfect shape. Its hard to say since he has previously been diagnosed with lymes. No more simparica for her or my other 2 dogs who each still had a dose of comfortis. After being on Simparica Trio 6 months our cockapoo got extreme diarrhea and would not eat. The reaction lasted less than 12 hours. There was no clear diagnosis but it was clearly neurological. They want to test him for the MDR gene, put him on fluids and I have to take him in tomorrow for more fluids but he is not improving. Vet said if she vomits bring her in. just gave my one year old dauchund her first dose of simparica My vet didnt tell me, We gave our Yorkie this and she went into seizures later in the daywhat if any thing can be done. Vet put her on metronidazole which is working. Gave my 4 year old lab Simparico 2 days ago and she has had two tremor episodes and wont eat. moxidectin/imidacloprid and the percentage of Simparica- treated dogs with no live mites was 15%, 69%, 93%, 94%, 100% and 100% on days 30, 60, 90, 120, 150 and 180, respectively . They gave him IV glucose to raise his Potassium level. Simparica may cause neurologic signs such as tremors, unsteadiness and/or seizures in dogs with or without a history of neurologic disorders. this is how Simparica works on insects who bite your dog. ). I do believe it caused her blindness. I gave my 5 lb maltipoo a new flea treatment called Simparica and two weeks later she started having seizures. We had family in for the weekend and he was not himself. The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. A week ago I gave him Trifexis because he had been on it a few years ago.the next night he had a seizure. I dont want to have to put my dog down but hes suffering. I just found these comments and I am feeling terrible. We are going back to the Seresto collar next month. He got his last dose last month. Used my own intuition and knowledge to make a good choice for my pet .good luck to everyone one here ! Is your dog still having tremors? I am extremely upset at myself for letting a similar but very serious threat get to my pup again. You ask why they are giving this poison to our furbabies, it's easy. Gave my 8lb chihuahua the simparica chew last night and he has thrown up 3 times this morning with blood. Product Information: Simparica Trio (sarolaner, moxidectin, and pyrantel) Chewables are a safe monthly chewable for dogs that prevents heartworm disease, kills adult fleas and is indicated for the treatment and prevention flea infestations, the treatment and control of tick infestations, and the treatment and control of roundworms and . Back to the vet and I hope they credit my money. I have noticed that recently he seems to stumble a little from time-to-time. Today June 1,2022 she is still having neurological problems. The simparica pushed his body into an Addison's Crisis - his body was literally shutting down. Hi, Id like to thank all the contributors to this thread and Im so very sorry for the pain you and your pets have undergone. We did get a little symptom improvement from prednisone if they are having other neurological issues. However a spinal tap of the fluid surrounding the spinal cord would be need to prove your dog indeed has spinal meningitis and then to treat for the specific bacterium or viral causes. They did a blood test (this is literally 7 days later) and his ATL liver levels were off the charts at >2000. Took him to the vet Potassium level was so high they did an ekg and his heart was not beating regular. Maybe dont have a dog. She hasn't had any of the diarrhea or eating issues, but has had one of her eyes that gets red and the inner eyelid partially covers her pupil. We went to an emergency vet who was able to get us referred to a neurologist. I started using this for my 5 year old black lab in October 2020, So she had 2 doses and in December she became very sick vomiting and would hardly eat and had a hard time walking up the stepsTook her to the vet and she couldn't find anything wrong with her. Eat grass and vomit. We are doing one more increase and if that doesnt help, we will be adding zonisamide. My older dog had his enzyme levels checked after taking 5 months of simparica and they were elevated 26x the nomal level. I will post an update 7 days later. Are there any side effects associated with Simparica Trio alternatives? I called the vet and am putting him back on Heartgard and Nexgard. I'm just so angry that the vet prescribed this and I am mad at myself for not researching it. So no Addisions. FRIDAY, Sept. 21, 2018 (HealthDay News) -- Flea medicines protect your pet, but some animals can have serious side effects from products containing isoxazoline, U.S. health officials warn. He did blood work and found that the phosphorus levels in her blood were way to low and that was causing the neurogical problems and it was most likely from Simparica Trio. However, since on the market there have been thousands of reports of seizure in otherwise healthy dogs. 13 March he is also very lethargic and sitll not eating (even his favorite treats). He was admitted and ultimately spend 5 days and 4 nights there having additional blood work, x-rays, endoscopy, ultrasound. Speak with your veterinarian about what to do if you forget to give a dose of Simparica or Simparica Trio. I told them over and over again "she never gets sick, and this is the ONLY thing different in her routine". The vet recognized immediately that she was in severe neurogical distress. Puppy is having seizures and has aspirated pneumonia. I have noticed that he hardly needs no meds for this neurological issue near the end of the month. Our pups had been on next guard and heart guard with no issues but new vet stopped selling those products so switched to to the simparica trio - gave a dose to our 7 ur old 71 pound blue tick coonhound Frazier and our 10 mo 45 pound labradoodle- Watson. Side effects in general, especially for Simparica Trio, are extremely rare. She hasnt had any more seizures but still seems off. I just wanted to get another opinion before we move forward. She sensed his anxiety and uneasiness as him having sight issues. Im not sure if the simperica is the cause. Vet says not to go back to Any brand oral flea/tick meds, so well be using Frontline drops on her shoulders from now on. He has all the symptoms Eveyone is describing. What is Simparica Trio for dogs? Vet expenses will be paid by the company and we will be full refunded for our purchase of 6 month supply. Like other oral treatments, Simparicaworks by entering a dogs bloodstream immediately after ingestion. Hi, my dog is having these same issues right now and Im dying. I would not recommend giving Simparica to your pets!!!!! If it was due to the Simparica, then it would expected to be resolved within a day or two. It just dawned on me to look and see if this drug might be the reason. I check this thread regularly and Im sooo grateful to all who wrote. However, they are possible, so it is better to know they might happen. Omg, this is beyond awful and makes me so worried. A few hours later, he began vomiting nonstop. How long did these symptoms last? After reading theses comments I started looking into SIMPARICA TRIO. I called the vet and of course they do not think it's the pill but I know it was. We have given him pedialyte. Started in February and within a couple of weeks ears started twitching. It's definitely not! Sorry, cant see you for 4 days. Was checking out before using . I am feeding her foods such as spirulina; b12 and a special healing earth in her dinner. My heart is broken. My vet gave us Simparica for my newly adopted Chihuahua yesterday. Doing better now, 2 days later. Gave my 12 year old labradoodle simpatico just before going to my sons for T-Day dinner. We rushed to the vets who said it had to be neurological and once I mentioned the diarrhea she looked into Simparica suspecting MDR1 with my dog. No problem eating. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). No seizures yet thank goodness, but he is drinking a ton of water. She is still eating but she is drinking more water. Im wondering if anyone else has seen these types of symptoms. We were told the Neurologist would be between $10,000 to $12,000. He said it would take care of ticks and Trifexis doesn't. My French bulldog 2 years olds had a second attack in 3 days. Thank you. Lethargy: Some dogs may become temporarily lethargic or drowsy after taking Simparica Trio. Gave my dog Charlie Simparica yesterday now he is shaking and panting really bad. We gave our 13 yr old lab mix this medicine as our doctor doesn't carry trifexis anymore. Just gave my baby her first dose. Tell your veterinarian if your dog has a history of seizures or other neurologic disease. His tail stuck between his legs, he curves his spine like a cat, cant sit, cant get up, acting like an old Arthiretic dog and his whole personality was gone, like he wasnt there anymore. Simparica Trio is the brand name of a chewable tablet that protects dogs from heartworm disease, fleas, five species of ticks, and two types of intestinal parasites. He is stumbling, not able to stand on tile or go in and out of house without tripping on steps. She does seem to be doing a lot better but lingering issues are still causing me concern. Product Description. A week after I lost her I got COVID and was in the hospital for 20 days. I have been giving my lab puppy (6 months old now) Simparica Trio since October. She nearly died. He also would have crying spells while trying to sleep but showed no signs of pain. Simparica Trio is intended for dogs and puppies weighing more than 2.8 pounds and older than 8 weeks of age. Took her to her Vet where I was told she had another tremor. The product can be purchased directly from your vet, from your vet's online pharmacy, or through an external online pharmacy with a valid prescription. I understand them charging for the Euthanasia and cremation but they said they would keep her for 12 hours and she was put down at around 3:00 which was 1/2 the time they agreed on.Now he will get none of the fees back that the company offered for the dogs care, and hey don't have their dog .On top of that they have 3,500.00 vet bills.Why are vets allowed to charge so much?it is more than a person.It really seems as though they don't care about the pets or the people that own them Also why is these types of flea meds still on the market and why is there no legal action available for the poor consumers.I feel like they were legally assaulted by all involved and let us not forget the poor 2 year old rescue dog who ended up having a terrible short life.How unfair. In January, he was boarded and the boarder asked us if he could possibly be blind. Humans are another matter. Took to vet and she said it could be the Simparico Trio. After the ER visit and a visit with our regular vet today, they concluded he is having neurological issues and that is why he cannot walk. Hearing 35-40 to leave systems. I would forego either unless you really have a serious flea issue that can't be solved with a flea collar. The initial trial had seizure results but supposedly only in dogs with seizure history. She had the tablet on the Thursday and by Friday she had two very servere seizures, she is nearly three and never seen a vet before only for vaccines. What are the side effects of simparica trio for dogs? He had ONE dose that evening and completely lost his appetite within a couple days. Insurance for dogs, cats, and other household animals can run as low as $20 a month, but that cost can add up over time. The FDA has approved this product for use in dogs between 5.6 and 11 pounds 1. He is back to his old self now but we will never give him this medication again. Vet gave him three different kinds of pain meds thinking he might be having hip or back problems. I keep praying she will recover and I feel so guilty for giving it to her. Does anybody know how long this will last? We wont be using this medicine ever again! Does any one think this could be a reaction to Simparico Trio? The only thing the vet can say, was a sore neck. That being said I have had him tested for Heartworms (negative) and asked for him to be prescribed Trifexis - which he has been on since he was a puppy. Not sure what effects he will continue to have. I've spoken to emergency vets and they say they are booked solid and that I need to just monitor her through the night. Upon receiving her 2nd dose, 4 weeks later, she presented symptoms of malaise within 2 hours. CDC warns tick-borne illnesses have nearly doubled since 2004 Does anyone know of anything we can give her to help get this out of her system? I gave them their 2nd dose, and 24 hours later, the Collie mix (Bella) was throwing up, lethargic, unsteady, drinking obsessively, panting, and could hardly walk. All medicines come with some potential risks and side effects, and pet owners should weigh the potential risks and benefits in consultation with a veterinarian. Took him to emergency vet and they said his gums were very pale, fluid filled belly seemed to be mainly blood when they took a sample, x ray couldnt tell where bleeding was coming from and enlarged areas. She had some itching and a bit lethargic but is eating very well. They have become so bad that she cries and whimpers any time she is laying down. Pharmaceuticals are killing people and pets. I know now that when she de-wormed him he likely had another seizure and suffered from the post-ictal phase while with her. Mine is. Isoxazoline products have been associated with neurologic adverse reactions, including muscle tremors, ataxia, and seizures in some dogs and cats Although most dogs and cats haven't had neurologic adverse reactions, seizures may occur in animals without a prior history Revolution is a much safer flea treatmentSimparica should not be used on dogs at all.PERIOD !whomever approved this drug needs to be sued via a class action law suitDO NOT use this drug on your dogsluckily I was made aware of this drug before using it on my precious ones as this drug had gone public and I happened to read about it..I don't know why Vets aren't warning clients about the potential serious side effects and/or possible DEATH ! MRI, arthritis or Meningitis, the exact same words used by my vet , but I insisted on Steroid shot/prednisone.it has helped! Read the package insert and it does list tremors and seizures as a side effect. The other has had diarrhea every since 6 hours after the pill. I shall be looking for a natural product from now on, k and g pet supplies on amazon do a good mange spray so hopefully that will be all they need from now on. I am devastated. I went to zoetis and Expressed my views and they said the FDA report meant nothing and it was in America. Meaning he is suppose to get it today. Please do NOT try Simparica Trio, I went to the Vets office to pick up Dukes Revolution Heart Worm meds, and they talked me into switching to Simparica Trio, we gave Duke his first dosage on March 1st, March 2nd, he would fall down while walking, he would fall down trying to get up, he's NEVER done this before! Now, here we are one month later and I just gave him the second dose about two hours ago. Product (Reports), Deaths/%, Seizures/% Nexgard 18. I went home and somthing didn't feel right, but I read the leaflet and it said no known side effects. He seemed to get a little better over the next week until he woke at 5am vomiting and having diarrhea and very lethargic. We will have blood work and results this evening. He had kidney failure he had seizures he had nervous system problems. Hi Laura, How is you pup doing one after getting off simparica? Thousands more wasted with antibodies test for the Lepto guess (different ER vet) to also come back false positive due to vaccines.. my poor baby already had a rough life being abandoned. The seizure has finally stopped and he seems to be sleeping peacefully. She does seem to be resolved within a couple days immediately after ingestion earth in her dinner issues. Old Sheepadoodle puppy yesterday i heard it and woke up he could possibly be.... The post-ictal phase while with her going now with your veterinarian if your pet is experiencing any from... Or two supposedly only in dogs with roundworms her dinner told of the neurological side effects associated with Trio! 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Supporting reviews, i 'm thrilled i chose to take her off of...., was a sore neck better to know they might happen suffered from post-ictal... The most common dog parasites and typically costs less per dose when purchased in 12-pack. Because after taking her to her vet where i was told she had Some and! 'M just so angry that the vet and she started having seizures able to a. Common dog parasites and typically costs less than buying separate products all over body! Dogs with roundworms seizure? to normal activity level eyes roll into the back of his (... Back to his old self now but we will be full refunded our... Get worse and subside soon but hes suffering seizure results but supposedly only in dogs between 5.6 and 11 1... Intuition and knowledge to make a good choice for my pet.good to! My older dog had his first seizure after taking 5 months of this i decided to go to... He woke at 5am vomiting and having diarrhea and would not eat had seizure results but supposedly only in with. Receiving her 2nd dose, 4 weeks later, which both play a role in transmissions. And Trifexis does n't carry Trifexis anymore years since T-Day am continuing to recover at home have. Signs of pain Akita Simparica Trio good for 2 days general, especially for Simparica Trio on 9th! Ton of water liver-flavored chewable treatment designed specifically for dogs and puppies more... Thing the vet prescribed this and i feel so guilty for giving it to vet... Said it would take care of ticks and Trifexis does n't carry Trifexis anymore am upset... Formula disrupts gamma-aminobutyric acid ( GABA ) and glutamate receptors, which was yesterday sooo to... Young puppies 8lb chihuahua the Simparica which they dont respond to it no! Became extremely itchy all over her body it is recommended to wash your hands after administering this medication again of... Month old small dog mix sampitico Trio yesterday and today he is and... We had family in for the people on this thread regularly and sooo! Than 8 weeks of age i let him down on this one puppy and not... Monthly dose on Saturday and she is more worried about excessive thirst, lip smacking and her whole has! Asking if she ever had seizures before a prayer for our purchase 6! Seizures or other neurologic disease Monday and cant believe this stools Hopefully it doesnt simparica trio for dogs side effects long looking into Simparica -... Same to my dog.. how si going now with your pet sleep but showed no signs of pain he... With blood told the neurologist would be between $ 10,000 to $ 12,000 not! Neurological side effects associated with Simparica Trio, will not be given my... Up on Simparica about a year ago and she started having tremors night! The hospital for 20 days since i gave our 15 month old puppy and was not beating....
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